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Five new acyl derivatives of isonicotinic acid hydrazide such as N-(2, 4-dichlorophenoxyacetyl)-isoniotinic acid hydrazide(I), N-(p-nitrobenzoyl)-isonicotinic acid hydrazide (II), N-benzoylisonicotinic acid hydrazide (III), N-furoylisonicotinic acid hydrazide (IV) and N-(p-aminobenzoyl)-isonicotinic acid hydrazide (V) were synthesized. They were obtained by the action of 2,4-dichlorophenylacetyl chloride, p-nitrobenzoyl chloride, benzoyl chloride, furoyl chloride and p-aminobenzoyl chloride with isonicotinic acid hydrazide in pyridine solution. Evaluated for their in vitro antitubercular activity against Mycobaterium tuberculosis H37 Rv N-furoylisonicotinic acid hydrazide (IV) showed antitubercular activity at 1gammar/ml.
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